| Speaker: Professor Timothy David Affiliation: The University of Canterbury Time: 2 pm Thursday, 27 September, 2018 Location: 303-257 |
| The talk will look at the cerebral phenomenon of neurovascular coupling (NVC), the ability to locally alter nutrient flow to cerebral tissue. We will define some concepts and provide a basic model using conservation principles and an electrical analogue. The presentation will present some of the difficulties associated with producing a viable (validated) model of complex phenomena which includes parameter vectors whose dimension is large and emanates from a variety of animal experiments. The results will concentrate on validation of NVC based on the stimulation of murine animals (barrel cortex) and then go on to investigate pathological conditions such as cortical spreading depression waves. Finally, we will enter into the world of global sensitivity analysis and discuss (with some new results) ways in which large parameter sets can be analysed to provide insight into the intricacies (and delicateness!) of cellular modelling. After that, I think we need to sit down and have a rest! |