Department of Mathematics
Title : Modeling the neuroprotective role of enhanced astrocyte mitochondrial metabolism during stroke
| Speaker: Professor David Terman Affiliation: Ohio State University, USA Time: 1 pm Thursday, 2 May, 2013 Location: Room 412 |
Abstract
| Cerebral ischemic stroke is the number 3 cause of death, trailing only cancer and heart disease, but current pharmacological treatments have not been successful. Recent experiments have demonstrated that stimulating calcium release in cells may provide neuroprotection following cerebral ischemic stroke. I will describe a mathematical model that confirms these experimental results. The model integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and ER Ca2+ handling, and IP3 production. The model is analyzed in order to better understand its mathematical behavior and to provide insights into the underlying biological data |
-
Programmes and Centres
- New Zealand Institute of Mathematics and its Applications (NZIMA)
- Community for Understanding and Learning in the Mathematical Sciences (CULMS)
- Centre for Mathematical Social Science (CMSS)
- Department of Computer Science
- Department of Engineering Science
- Department of Physics
- Department of Statistics
- Auckland Bioengineering Institute
